[15] Queretaro Women 4-2 Santos Laguna Women [4] 2021-11-13 23:00
Stadium: Estadio La Corregidora Round: 16
Head to Head
| Mexico Liga MX Femenil | 2021/02/09 01:00 | Santos Laguna Women v Queretaro Women | W | 1-2 |
| Mexico Liga MX Femenil | 2020/10/19 17:00 | Queretaro Women v Santos Laguna Women | W | 2-1 |
| Mexico Liga MX Femenil | 2019/08/02 21:00 | Queretaro Women v Santos Laguna Women | W | 1-0 |
| Mexico Liga MX Femenil | 2019/03/26 03:00 | Santos Laguna Women v Queretaro Women | L | 2-1 |
| Mexico Liga MX Femenil | 2019/01/28 22:00 | Queretaro Women v Santos Laguna Women | W | 4-0 |
| Mexico Liga MX Femenil | 2018/10/23 02:00 | Santos Laguna Women v Queretaro Women | D | 2-2 |
| Mexico Liga MX Femenil | 2018/08/10 21:00 | Queretaro Women v Santos Laguna Women | W | 3-1 |
| Mexico Liga MX Femenil | 2018/03/03 17:00 | Queretaro Women v Santos Laguna Women | L | 1-2 |
Home History
| Mexico Liga MX Femenil | 2021/11/07 16:30 | Chivas Guadalajara Women v Queretaro Women | W | 0-2 |
| Mexico Liga MX Femenil | 2021/10/29 22:00 | Queretaro Women v Cruz Azul Women | L | 1-2 |
| Mexico Liga MX Femenil | 2021/10/15 22:00 | Queretaro Women v Toluca Women | L | 0-1 |
| Mexico Liga MX Femenil | 2021/10/09 01:00 | Mazatlan FC Women v Queretaro Women | L | 1-0 |
| Mexico Liga MX Femenil | 2021/10/04 22:00 | Club Necaxa Women v Queretaro Women | L | 2-0 |
| Mexico Liga MX Femenil | 2021/09/24 22:00 | Queretaro Women v Atletico San Luis Women | D | 1-1 |
| Mexico Liga MX Femenil | 2021/09/12 17:00 | Puebla Women v Queretaro Women | W | 0-1 |
| Mexico Liga MX Femenil | 2021/09/03 22:00 | Queretaro Women v Tigres UANL Women | L | 1-2 |
Away History
| Mexico Liga MX Femenil | 2021/11/09 01:00 | Pachuca Women v Santos Laguna Women | L | 4-0 |
| Mexico Liga MX Femenil | 2021/11/02 03:00 | Santos Laguna Women v Atletico San Luis Women | W | 3-1 |
| Mexico Liga MX Femenil | 2021/10/18 22:00 | Santos Laguna Women v Unam Pumas Women | W | 2-0 |
| Mexico Liga MX Femenil | 2021/10/09 21:00 | Toluca Women v Santos Laguna Women | L | 1-0 |
| Mexico Liga MX Femenil | 2021/10/05 02:00 | Juarez FC Women v Santos Laguna Women | W | 1-2 |
| Mexico Liga MX Femenil | 2021/09/27 22:00 | Santos Laguna Women v Monterrey Women | D | 2-2 |
| Mexico Liga MX Femenil | 2021/09/13 02:00 | Santos Laguna Women v Chivas Guadalajara Women | W | 5-4 |
| Mexico Liga MX Femenil | 2021/09/05 17:00 | Puebla Women v Santos Laguna Women | W | 2-3 |