[7] Cerro Largo 0-1 Penarol [4] 2021-08-06 21:00
Stadium: Estadio Arquitecto Antonio Eleuterio Ubilla Round: 13
Referee: Gustavo Tejera Home Manager: Luis Danielo Nunez Maciel Away Manager: Mauricio Larriera
Head to Head
| Copa Sudamericana | 2021/04/14 00:30 | Penarol v Cerro Largo | L | 4-1 |
| Copa Sudamericana | 2021/04/07 00:30 | Cerro Largo v Penarol | D | 2-2 |
| Uruguay Clausura | 2021/02/17 22:30 | Cerro Largo v Penarol | D | 1-1 |
| Uruguay Apertura | 2020/08/27 23:15 | Penarol v Cerro Largo | L | 2-0 |
| Uruguay Clausura | 2019/12/05 23:30 | Penarol v Cerro Largo | L | 2-1 |
| Uruguay Apertura | 2019/06/02 19:00 | Cerro Largo v Penarol | W | 1-0 |
Home History
| Uruguay Apertura | 2021/07/30 18:00 | Rentistas v Cerro Largo | W | 1-3 |
| Uruguay Apertura | 2021/07/17 20:15 | Cerro Largo v Montevideo Wanderers | W | 2-0 |
| Uruguay Apertura | 2021/07/11 15:15 | Boston River v Cerro Largo | L | 1-0 |
| Uruguay Apertura | 2021/07/03 19:15 | Cerro Largo v Atletico Fenix Montevideo | L | 1-2 |
| Uruguay Apertura | 2021/06/28 18:00 | Plaza Colonia v Cerro Largo | D | 1-1 |
| Uruguay Apertura | 2021/06/22 20:15 | Cerro Largo v IA Sud America | W | 2-1 |
| Uruguay Apertura | 2021/06/19 15:15 | Club Atletico Progreso v Cerro Largo | D | 0-0 |
| Uruguay Apertura | 2021/06/13 15:30 | Deportivo Maldonado v Cerro Largo | L | 2-1 |
Away History
| Uruguay Apertura | 2021/08/01 21:00 | Penarol v CA River Plate | W | 2-0 |
| Uruguay Apertura | 2021/07/25 18:00 | Liverpool Montevideo v Penarol | D | 3-3 |
| Copa Sudamericana | 2021/07/23 00:30 | Penarol v Nacional De Football | L | 0-1 |
| Copa Sudamericana | 2021/07/16 00:30 | Nacional De Football v Penarol | W | 1-2 |
| Uruguay Apertura | 2021/07/11 23:30 | Penarol v Cerrito | W | 2-0 |
| Uruguay Apertura | 2021/07/04 19:00 | Nacional De Football v Penarol | L | 2-0 |
| Uruguay Apertura | 2021/06/26 21:00 | Penarol v Villa Espanola | D | 1-1 |
| Uruguay Apertura | 2021/06/23 18:45 | Torque v Penarol | W | 0-1 |