[7] Cerro Largo 0-1 Penarol [4] 2021-08-06 21:00
Stadium: Estadio Arquitecto Antonio Eleuterio Ubilla Round: 13
Referee: Gustavo Tejera Home Manager: Luis Danielo Nunez Maciel Away Manager: Mauricio Larriera
Head to Head
| Copa Sudamericana | 2021/04/14 00:30 | Penarol v Cerro Largo | L | 4-1 |
| Copa Sudamericana | 2021/04/07 00:30 | Cerro Largo v Penarol | D | 2-2 |
| Uruguay Clausura | 2021/02/17 22:30 | Cerro Largo v Penarol | D | 1-1 |
| Uruguay Apertura | 2020/08/27 23:15 | Penarol v Cerro Largo | L | 2-0 |
| Uruguay Clausura | 2019/12/05 23:30 | Penarol v Cerro Largo | L | 2-1 |
| Uruguay Apertura | 2019/06/02 19:00 | Cerro Largo v Penarol | W | 1-0 |