[6] America de Cali 1-0 Once Caldas [13] 2021-08-07 20:00
Weather: Good Stadium: Olimpico Pascual Guerrero Pitch: Good Round: 4
Referee: Home Manager: Juan Carlos Osorio Away Manager: Eduardo Lara Lozano
Head to Head
| Colombia Primera A | 2021/03/21 01:00 | Once Caldas v America de Cali | D | 1-1 |
| Colombia Primera A | 2020/03/07 21:40 | Once Caldas v America de Cali | D | 1-1 |
| Colombia Primera A | 2019/08/31 22:00 | Once Caldas v America de Cali | L | 2-1 |
| Colombia Cup | 2019/08/14 23:00 | America de Cali v Once Caldas | D | 0-0 |
| Colombia Cup | 2019/08/01 00:30 | Once Caldas v America de Cali | L | 2-1 |
| Colombia Primera A | 2019/03/11 01:00 | America de Cali v Once Caldas | W | 3-1 |
| Colombia Primera A | 2018/11/04 23:00 | America de Cali v Once Caldas | D | 1-1 |
| Colombia Primera A | 2018/04/29 23:00 | Once Caldas v America de Cali | D | 2-2 |
Home History
| Colombia Primera A | 2021/08/01 21:00 | Envigado FC v America de Cali | L | 1-0 |
| Colombia Primera A | 2021/07/24 20:30 | Aguilas Doradas v America de Cali | W | 1-3 |
| Copa Sudamericana | 2021/07/21 00:30 | Athletico Paranaense v America de Cali | L | 4-1 |
| Colombia Primera A | 2021/07/17 20:30 | America de Cali v Junior | W | 3-1 |
| Copa Sudamericana | 2021/07/14 00:30 | America de Cali v Athletico Paranaense | L | 0-1 |
| Copa Libertadores | 2021/05/26 00:30 | Cerro Porteno v America de Cali | L | 1-0 |
| Copa Libertadores | 2021/05/20 02:00 | America de Cali v Deportivo La Guaira | W | 3-1 |
| Copa Libertadores | 2021/05/14 00:00 | America de Cali v Atletico Mineiro | L | 1-3 |
Away History
| Colombia Cup | 2021/08/04 22:40 | Once Caldas v Independiente Medellin | L | 1-3 |
| Colombia Primera A | 2021/08/01 23:05 | Once Caldas v Millonarios | L | 0-2 |
| Colombia Cup | 2021/07/29 01:05 | Independiente Medellin v Once Caldas | D | 1-1 |
| Colombia Primera A | 2021/07/24 22:40 | Jaguares de Cordoba v Once Caldas | D | 1-1 |
| Colombia Primera A | 2021/07/19 23:00 | Once Caldas v Atletico Huila | W | 1-0 |
| Colombia Primera A | 2021/04/18 21:30 | Once Caldas v Independiente Medellin | W | 2-0 |
| Colombia Primera A | 2021/04/14 01:00 | Patriotas FC v Once Caldas | D | 1-1 |
| Colombia Primera A | 2021/04/06 01:00 | Once Caldas v Jaguares de Cordoba | L | 1-2 |