[6] America de Cali 1-0 Once Caldas [13] 2021-08-07 20:00
Weather: Good Stadium: Olimpico Pascual Guerrero Pitch: Good Round: 4
Referee: Home Manager: Juan Carlos Osorio Away Manager: Eduardo Lara Lozano
Head to Head
| Colombia Primera A | 2021/03/21 01:00 | Once Caldas v America de Cali | D | 1-1 |
| Colombia Primera A | 2020/03/07 21:40 | Once Caldas v America de Cali | D | 1-1 |
| Colombia Primera A | 2019/08/31 22:00 | Once Caldas v America de Cali | L | 2-1 |
| Colombia Cup | 2019/08/14 23:00 | America de Cali v Once Caldas | D | 0-0 |
| Colombia Cup | 2019/08/01 00:30 | Once Caldas v America de Cali | L | 2-1 |
| Colombia Primera A | 2019/03/11 01:00 | America de Cali v Once Caldas | W | 3-1 |
| Colombia Primera A | 2018/11/04 23:00 | America de Cali v Once Caldas | D | 1-1 |
| Colombia Primera A | 2018/04/29 23:00 | Once Caldas v America de Cali | D | 2-2 |
| Colombia Primera A | 2017/09/24 01:00 | Once Caldas v America de Cali | D | 0-0 |
| Colombia Primera A | 2017/04/16 22:15 | America de Cali v Once Caldas | W | 4-2 |