[67] East Carolina 30-29 Memphis [59] 2021-11-13 17:00
Stadium: Liberty Bowl Memorial Stadium Round: 1
Home Manager: Ryan Silverfield Away Manager: Mike Houston
Head to Head
| NCAAF | 2018/11/03 16:00 | Memphis v East Carolina | L | 59-41 |
| NCAAF | 2017/11/25 17:00 | East Carolina v Memphis | L | 13-70 |
| NCAAF | 2012/10/13 12:00 | East Carolina v Memphis | W | 41-7 |
| NCAAF | 2011/10/15 12:00 | Memphis v East Carolina | W | 17-35 |
| NCAAF | 2010/09/11 12:00 | East Carolina v Memphis | W | 49-27 |
| NCAAF | 2009/10/27 12:00 | Memphis v East Carolina | W | 19-38 |
| NCAAF | 2008/10/18 12:00 | East Carolina v Memphis | W | 30-10 |
| NCAAF | 2007/11/03 12:00 | Memphis v East Carolina | W | 40-56 |
Home History
| NCAAF | 2021/11/06 19:00 | Temple v East Carolina | W | 3-45 |
| NCAAF | 2021/10/28 23:30 | South Florida v East Carolina | W | 14-29 |
| NCAAF | 2021/10/24 01:20 | East Carolina v Houston | L | 24-31 |
| NCAAF | 2021/10/09 22:00 | East Carolina v Central Florida | L | 16-20 |
| NCAAF | 2021/10/02 19:30 | Tulane v East Carolina | W | 29-52 |
| NCAAF | 2021/09/25 22:00 | Charleston Southern v East Carolina | W | 28-31 |
| NCAAF | 2021/09/18 22:00 | East Carolina v Marshall | W | 42-38 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | L | 20-17 |
Away History
| NCAAF | 2021/11/06 16:00 | SMU v Memphis | W | 25-28 |
| NCAAF | 2021/10/22 23:00 | Memphis v Central Florida | L | 7-24 |
| NCAAF | 2021/10/14 23:30 | Navy v Memphis | W | 17-35 |
| NCAAF | 2021/10/10 01:00 | Memphis v Tulsa | L | 29-35 |
| NCAAF | 2021/10/02 16:00 | Memphis v Temple | L | 31-34 |
| NCAAF | 2021/09/25 19:30 | Texas-San Antonio v Memphis | L | 31-28 |
| NCAAF | 2021/09/18 20:00 | Mississippi State v Memphis | W | 29-31 |
| NCAAF | 2021/09/11 23:00 | Memphis v Arkansas State | W | 55-50 |