[51] Auburn 17-21 South Carolina [78] 2021-11-21 00:00
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Shane Beamer Away Manager: Bryan Harsin
Head to Head
| NCAAF | 2020/10/17 16:00 | Auburn v South Carolina | L | 22-30 |
| NCAAF | 2014/10/25 23:30 | Auburn v South Carolina | W | 42-35 |
| NCAAF | 2011/10/01 12:00 | South Carolina v Auburn | W | 13-16 |
| NCAAF | 2010/12/04 12:00 | Auburn v South Carolina | W | 56-17 |
| NCAAF | 2010/09/25 12:00 | Auburn v South Carolina | W | 35-27 |
| NCAAF | 2006/09/28 12:00 | South Carolina v Auburn | W | 17-24 |
| NCAAF | 2005/10/01 12:00 | Auburn v South Carolina | W | 48-7 |
Home History
| NCAAF | 2021/11/13 17:00 | Mississippi State v Auburn | L | 43-34 |
| NCAAF | 2021/11/06 19:30 | Auburn v Texas A&M | L | 3-20 |
| NCAAF | 2021/10/30 23:00 | Mississippi v Auburn | W | 20-31 |
| NCAAF | 2021/10/16 16:00 | Auburn v Arkansas | W | 38-23 |
| NCAAF | 2021/10/09 19:30 | Georgia v Auburn | L | 34-10 |
| NCAAF | 2021/10/03 01:00 | Auburn v LSU | W | 24-19 |
| NCAAF | 2021/09/25 20:00 | Georgia State v Auburn | W | 24-34 |
| NCAAF | 2021/09/18 23:30 | Auburn v Penn State | L | 20-28 |
Away History
| NCAAF | 2021/11/13 21:00 | South Carolina v Missouri | L | 28-31 |
| NCAAF | 2021/11/06 23:30 | Florida v South Carolina | W | 17-40 |
| NCAAF | 2021/10/23 23:30 | South Carolina v Texas A&M | L | 14-44 |
| NCAAF | 2021/10/16 20:00 | Vanderbilt v South Carolina | W | 20-21 |
| NCAAF | 2021/10/09 16:00 | South Carolina v Tennessee | L | 20-45 |
| NCAAF | 2021/10/02 19:30 | Troy v South Carolina | W | 14-23 |
| NCAAF | 2021/09/25 23:00 | Kentucky v South Carolina | L | 16-10 |
| NCAAF | 2021/09/18 23:00 | South Carolina v Georgia | L | 13-40 |