[51] Auburn 17-21 South Carolina [78] 2021-11-21 00:00
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Shane Beamer Away Manager: Bryan Harsin
Head to Head
| NCAAF | 2020/10/17 16:00 | Auburn v South Carolina | L | 22-30 |
| NCAAF | 2014/10/25 23:30 | Auburn v South Carolina | W | 42-35 |
| NCAAF | 2011/10/01 12:00 | South Carolina v Auburn | W | 13-16 |
| NCAAF | 2010/12/04 12:00 | Auburn v South Carolina | W | 56-17 |
| NCAAF | 2010/09/25 12:00 | Auburn v South Carolina | W | 35-27 |
| NCAAF | 2006/09/28 12:00 | South Carolina v Auburn | W | 17-24 |
| NCAAF | 2005/10/01 12:00 | Auburn v South Carolina | W | 48-7 |