[24] Pittsburgh 54-29 Duke [97] 2021-11-06 16:00
Stadium: Brooks Field at Wallace Wade Stadium Round: 1
Home Manager: David Cutcliffe Away Manager: Pat Narduzzi
Head to Head
| NCAAF | 2019/10/06 00:00 | Pittsburgh v Duke | W | 33-30 |
| NCAAF | 2018/10/27 19:30 | Duke v Pittsburgh | W | 45-54 |
| NCAAF | 2017/10/21 16:20 | Pittsburgh v Duke | W | 24-17 |
| NCAAF | 2016/11/19 20:00 | Duke v Pittsburgh | W | 14-56 |
| NCAAF | 2015/11/14 17:00 | Duke v Pittsburgh | W | 13-31 |
| NCAAF | 2014/11/01 16:00 | Pittsburgh v Duke | L | 48-51 |
Home History
| NCAAF | 2021/10/30 16:00 | Miami Florida v Pittsburgh | L | 38-34 |
| NCAAF | 2021/10/23 19:30 | Clemson v Pittsburgh | W | 17-27 |
| NCAAF | 2021/10/16 19:30 | Pittsburgh v Virginia Tech | W | 28-7 |
| NCAAF | 2021/10/02 16:00 | Pittsburgh v Georgia Tech | W | 52-21 |
| NCAAF | 2021/09/25 16:00 | New Hampshire v Pittsburgh | W | 7-77 |
| NCAAF | 2021/09/18 16:00 | Western Michigan v Pittsburgh | L | 44-41 |
| NCAAF | 2021/09/11 16:00 | Pittsburgh v Tennessee | W | 41-34 |
| NCAAF | 2021/09/04 20:00 | Massachusetts v Pittsburgh | W | 7-51 |
Away History
| NCAAF | 2021/10/30 20:00 | Duke v Wake Forest | L | 7-45 |
| NCAAF | 2021/10/16 16:30 | Duke v Virginia | L | 0-48 |
| NCAAF | 2021/10/09 16:30 | Georgia Tech v Duke | L | 31-27 |
| NCAAF | 2021/10/02 16:00 | Duke v North Carolina | L | 7-38 |
| NCAAF | 2021/09/25 20:00 | Kansas v Duke | W | 33-52 |
| NCAAF | 2021/09/18 20:00 | Northwestern v Duke | W | 23-30 |
| NCAAF | 2021/09/11 00:00 | North Carolina A&T v Duke | W | 17-45 |
| NCAAF | 2021/09/03 23:00 | Duke v Charlotte | L | 28-31 |