[24] Pittsburgh 54-29 Duke [97] 2021-11-06 16:00
Stadium: Brooks Field at Wallace Wade Stadium Round: 1
Home Manager: David Cutcliffe Away Manager: Pat Narduzzi
Head to Head
| NCAAF | 2019/10/06 00:00 | Pittsburgh v Duke | W | 33-30 |
| NCAAF | 2018/10/27 19:30 | Duke v Pittsburgh | W | 45-54 |
| NCAAF | 2017/10/21 16:20 | Pittsburgh v Duke | W | 24-17 |
| NCAAF | 2016/11/19 20:00 | Duke v Pittsburgh | W | 14-56 |
| NCAAF | 2015/11/14 17:00 | Duke v Pittsburgh | W | 13-31 |
| NCAAF | 2014/11/01 16:00 | Pittsburgh v Duke | L | 48-51 |