Stadium: Robert W. Plaster Stadium Round: 1
Home Manager: Bobby Petrino Away Manager: Bubba Schweigert
| NCAAF | 2021/04/24 20:00 | Missouri St v North Dakota | W | 10-44 |
| NCAAF | 2017/09/09 21:00 | North Dakota v Missouri St | W | 34-0 |
| NCAAF | 2021/10/23 19:00 | Western Illinois v North Dakota | W | 10-34 |
| NCAAF | 2021/10/16 19:00 | North Dakota v SO Illinois | L | 28-31 |
| NCAAF | 2021/10/09 19:00 | North Dakota v South Dakota | L | 13-20 |
| NCAAF | 2021/10/02 19:00 | North Dakota State v North Dakota | L | 16-10 |
| NCAAF | 2021/09/18 21:00 | Drake Bulldogs v North Dakota | W | 0-38 |
| NCAAF | 2021/09/11 01:00 | North Dakota v Utah State | L | 24-48 |
| NCAAF | 2021/09/04 19:00 | North Dakota v Idaho State | W | 35-14 |
| NCAAF | 2021/05/02 22:00 | North Dakota v James Madison | L | 21-34 |
| NCAAF | 2021/10/23 19:30 | Missouri St v North Dakota State | L | 20-27 |
| NCAAF | 2021/10/16 19:00 | Indiana State v Missouri St | W | 7-37 |
| NCAAF | 2021/10/09 18:00 | Missouri St v Youngstown State | L | 33-41 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | W | 41-20 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | W | 23-31 |
| NCAAF | 2021/09/12 00:00 | Central Arkansas v Missouri St | W | 34-43 |
| NCAAF | 2021/09/04 23:00 | Missouri St v Oklahoma State | L | 16-23 |
| NCAAF | 2021/04/24 20:00 | Missouri St v North Dakota | L | 10-44 |