Illinois State 17-35 Southern Illinois 2021-09-25 19:00
Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Brock Spack
Head to Head
| NCAAF | 2019/10/12 23:00 | Illinois State v SO Illinois | W | 21-7 |
| NCAAF | 2018/10/13 19:00 | SO Illinois v Illinois State | W | 3-51 |
| NCAAF | 2017/10/14 19:00 | SO Illinois v Illinois State | L | 42-7 |
Home History
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | W | 31-24 |
| NCAAF | 2021/09/11 21:00 | Illinois State v Western Michigan | L | 0-28 |
| NCAAF | 2021/09/04 23:30 | Butler v Illinois State | W | 7-49 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | W | 18-26 |
| NCAAF | 2021/03/13 20:30 | Illinois State v North Dakota State | L | 13-21 |
| NCAAF | 2021/03/06 22:00 | Illinois State v Northern Iowa | L | 10-20 |
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | L | 27-20 |
| NCAAF | 2019/12/14 17:00 | Illinois State v North Dakota State | L | 3-9 |
Away History
| NCAAF | 2021/09/18 23:00 | Dayton v SO Illinois | W | 3-55 |
| NCAAF | 2021/09/11 23:00 | SO Illinois v Kansas State | L | 23-31 |
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | W | 47-21 |
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | L | 26-31 |
| NCAAF | 2021/04/24 20:00 | SO Illinois v Weber State | W | 34-31 |
| NCAAF | 2021/04/17 17:00 | SE Louisiana v SO Illinois | W | 48-55 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | L | 27-30 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | L | 44-3 |