Missouri State 38-28 Southern Illinois 2021-11-06 17:00
Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Bobby Petrino
Head to Head
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | W | 27-30 |
| NCAAF | 2019/11/09 20:00 | Missouri St v SO Illinois | L | 14-37 |
| NCAAF | 2018/10/27 19:00 | Missouri St v SO Illinois | L | 35-49 |
| NCAAF | 2017/11/04 18:00 | SO Illinois v Missouri St | W | 28-36 |
Home History
| NCAAF | 2021/10/30 19:00 | North Dakota v Missouri St | W | 28-32 |
| NCAAF | 2021/10/23 19:30 | Missouri St v North Dakota State | L | 20-27 |
| NCAAF | 2021/10/16 19:00 | Indiana State v Missouri St | W | 7-37 |
| NCAAF | 2021/10/09 18:00 | Missouri St v Youngstown State | L | 33-41 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | W | 41-20 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | W | 23-31 |
| NCAAF | 2021/09/12 00:00 | Central Arkansas v Missouri St | W | 34-43 |
| NCAAF | 2021/09/04 23:00 | Missouri St v Oklahoma State | L | 16-23 |
Away History
| NCAAF | 2021/10/30 21:00 | SO Illinois v Northern Iowa | L | 16-23 |
| NCAAF | 2021/10/16 19:00 | North Dakota v SO Illinois | W | 28-31 |
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | W | 42-41 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | W | 31-30 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | W | 17-35 |
| NCAAF | 2021/09/18 23:00 | Dayton v SO Illinois | W | 3-55 |
| NCAAF | 2021/09/11 23:00 | SO Illinois v Kansas State | L | 23-31 |
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | W | 47-21 |