Stadium: Hancock Stadium Round: 1
Home Manager: Brock Spack Away Manager: Bobby Petrino
| NCAAF | 2019/11/16 18:00 | Missouri St v Illinois State | L | 12-17 |
| NCAAF | 2018/09/29 19:00 | Illinois State v Missouri St | W | 21-24 |
| NCAAF | 2017/09/23 19:00 | Missouri St v Illinois State | L | 9-34 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | W | 23-31 |
| NCAAF | 2021/09/12 00:00 | Central Arkansas v Missouri St | W | 34-43 |
| NCAAF | 2021/09/04 23:00 | Missouri St v Oklahoma State | L | 16-23 |
| NCAAF | 2021/04/24 20:00 | Missouri St v North Dakota | L | 10-44 |
| NCAAF | 2021/04/10 19:00 | Youngstown State v Missouri St | W | 10-21 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | W | 27-30 |
| NCAAF | 2021/03/20 21:00 | Missouri St v Northern Iowa | W | 13-6 |
| NCAAF | 2021/03/13 19:00 | Missouri St v South Dakota | W | 27-24 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | L | 17-35 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | W | 31-24 |
| NCAAF | 2021/09/11 21:00 | Illinois State v Western Michigan | L | 0-28 |
| NCAAF | 2021/09/04 23:30 | Butler v Illinois State | W | 7-49 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | W | 18-26 |
| NCAAF | 2021/03/13 20:30 | Illinois State v North Dakota State | L | 13-21 |
| NCAAF | 2021/03/06 22:00 | Illinois State v Northern Iowa | L | 10-20 |
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | L | 27-20 |