Southern Illinois 47-21 Indiana State 2021-11-13 18:00
Stadium: Memorial Stadium (Terre Haute) Round: 1
Home Manager: Curt Mallory Away Manager: Nick Hill
Head to Head
| NCAAF | 2019/11/02 17:00 | SO Illinois v Indiana State | W | 23-14 |
| NCAAF | 2018/10/20 19:00 | SO Illinois v Indiana State | L | 21-24 |
| NCAAF | 2017/10/21 19:00 | Indiana State v SO Illinois | W | 24-45 |
Home History
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | L | 38-28 |
| NCAAF | 2021/10/30 21:00 | SO Illinois v Northern Iowa | L | 16-23 |
| NCAAF | 2021/10/16 19:00 | North Dakota v SO Illinois | W | 28-31 |
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | W | 42-41 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | W | 31-30 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | W | 17-35 |
| NCAAF | 2021/09/18 23:00 | Dayton v SO Illinois | W | 3-55 |
| NCAAF | 2021/09/11 23:00 | SO Illinois v Kansas State | L | 23-31 |
Away History
| NCAAF | 2021/10/30 19:30 | Indiana State v North Dakota State | L | 2-44 |
| NCAAF | 2021/10/23 17:00 | Youngstown State v Indiana State | W | 17-28 |
| NCAAF | 2021/10/16 19:00 | Indiana State v Missouri St | L | 7-37 |
| NCAAF | 2021/10/09 17:00 | Western Illinois v Indiana State | W | 27-37 |
| NCAAF | 2021/10/02 19:00 | Indiana State v South Dakota | L | 10-38 |
| NCAAF | 2021/09/25 17:00 | South Dakota State v Indiana State | L | 44-0 |
| NCAAF | 2021/09/18 23:00 | Indiana State v Eastern Kentucky | W | 23-21 |
| NCAAF | 2021/09/11 16:00 | Indiana State v Northwestern | L | 6-24 |