Stadium: Hancock Stadium Round: 1
Home Manager: Brock Spack Away Manager: Curt Mallory
| NCAAF | 2019/10/26 19:00 | Indiana State v Illinois State | L | 7-24 |
| NCAAF FCS | 2018/11/10 18:00 | Illinois State v Indiana State | W | 23-28 |
| NCAAF | 2017/09/30 23:30 | Illinois State v Indiana State | L | 24-13 |
| NCAAF | 2021/11/13 18:00 | SO Illinois v Indiana State | L | 47-21 |
| NCAAF | 2021/10/30 19:30 | Indiana State v North Dakota State | L | 2-44 |
| NCAAF | 2021/10/23 17:00 | Youngstown State v Indiana State | W | 17-28 |
| NCAAF | 2021/10/16 19:00 | Indiana State v Missouri St | L | 7-37 |
| NCAAF | 2021/10/09 17:00 | Western Illinois v Indiana State | W | 27-37 |
| NCAAF | 2021/10/02 19:00 | Indiana State v South Dakota | L | 10-38 |
| NCAAF | 2021/09/25 17:00 | South Dakota State v Indiana State | L | 44-0 |
| NCAAF | 2021/09/18 23:00 | Indiana State v Eastern Kentucky | W | 23-21 |
| NCAAF | 2021/11/13 20:00 | Illinois State v North Dakota | L | 7-14 |
| NCAAF | 2021/11/06 17:00 | Northern Iowa v Illinois State | W | 10-17 |
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | L | 31-38 |
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | W | 20-14 |
| NCAAF | 2021/10/16 19:00 | North Dakota State v Illinois State | L | 20-0 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | L | 41-20 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | L | 17-35 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | W | 31-24 |