[12] Southern Illinois 16-23 Northern Iowa [56] 2021-10-30 21:00
Stadium: UNI-Dome Round: 1
Home Manager: Mark Farley Away Manager: Nick Hill
Head to Head
| NCAAF | 2021/03/13 18:00 | Northern Iowa v SO Illinois | W | 16-17 |
| NCAAF | 2017/09/30 23:00 | SO Illinois v Northern Iowa | L | 17-24 |
Home History
| NCAAF | 2021/10/16 19:00 | North Dakota v SO Illinois | W | 28-31 |
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | W | 42-41 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | W | 31-30 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | W | 17-35 |
| NCAAF | 2021/09/18 23:00 | Dayton v SO Illinois | W | 3-55 |
| NCAAF | 2021/09/11 23:00 | SO Illinois v Kansas State | L | 23-31 |
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | W | 47-21 |
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | L | 26-31 |
Away History
| NCAAF | 2021/10/23 19:00 | Northern Iowa v South Dakota State | W | 26-17 |
| NCAAF | 2021/10/16 21:00 | South Dakota v Northern Iowa | L | 34-21 |
| NCAAF | 2021/10/09 18:00 | Northern Iowa v North Dakota State | L | 20-34 |
| NCAAF | 2021/10/02 21:00 | Youngstown State v Northern Iowa | W | 7-34 |
| NCAAF | 2021/09/12 01:00 | Northern Iowa v CS Sacramento | W | 34-16 |
| NCAAF | 2021/09/04 20:30 | Northern Iowa v Iowa State | L | 10-16 |
| NCAAF | 2021/04/10 21:00 | North Dakota State v Northern Iowa | L | 23-20 |
| NCAAF | 2021/03/27 16:00 | Northern Iowa v Western Illinois | W | 34-20 |