North Dakota 13-20 South Dakota 2021-10-09 19:00
Stadium: DakotaDome Round: 1
Home Manager: Bob Nielson Away Manager: Bubba Schweigert
Head to Head
| NCAAF | 2021/03/04 23:00 | South Dakota v North Dakota | W | 10-21 |
| NCAAF | 2017/09/16 19:00 | South Dakota v North Dakota | L | 45-7 |
Home History
| NCAAF | 2021/10/02 19:00 | North Dakota State v North Dakota | L | 16-10 |
| NCAAF | 2021/09/18 21:00 | Drake Bulldogs v North Dakota | W | 0-38 |
| NCAAF | 2021/09/11 01:00 | North Dakota v Utah State | L | 24-48 |
| NCAAF | 2021/09/04 19:00 | North Dakota v Idaho State | W | 35-14 |
| NCAAF | 2021/05/02 22:00 | North Dakota v James Madison | L | 21-34 |
| NCAAF | 2021/04/24 20:00 | Missouri St v North Dakota | W | 10-44 |
| NCAAF | 2021/03/20 19:30 | North Dakota v North Dakota State | L | 13-34 |
| NCAAF | 2021/03/13 18:00 | North Dakota v Western Illinois | W | 38-21 |
Away History
| NCAAF | 2021/10/02 19:00 | Indiana State v South Dakota | W | 10-38 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | L | 23-31 |
| NCAAF | 2021/09/19 00:00 | South Dakota v Cal Poly | W | 48-14 |
| NCAAF | 2021/09/11 18:00 | Northern Arizona v South Dakota | W | 7-34 |
| NCAAF | 2021/09/04 00:00 | South Dakota v Kansas | L | 14-17 |
| NCAAF | 2021/03/20 16:00 | South Dakota v Youngstown State | L | 10-28 |
| NCAAF | 2021/03/13 19:00 | Missouri St v South Dakota | L | 27-24 |
| NCAAF | 2021/03/04 23:00 | South Dakota v North Dakota | L | 10-21 |