South Dakota 42-21 Western Illinois 2021-11-06 17:00
Stadium: Hanson Field Round: 1
Home Manager: Jared Elliott Away Manager: Bob Nielson
Head to Head
| NCAAF | 2019/11/02 18:00 | South Dakota v Western Illinois | L | 34-38 |
| NCAAF FCS | 2018/11/10 19:00 | Western Illinois v South Dakota | W | 12-17 |
| NCAAF | 2017/09/30 20:00 | Western Illinois v South Dakota | W | 33-38 |
Home History
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | L | 20-14 |
| NCAAF | 2021/10/16 21:00 | South Dakota v Northern Iowa | W | 34-21 |
| NCAAF | 2021/10/09 19:00 | North Dakota v South Dakota | W | 13-20 |
| NCAAF | 2021/10/02 19:00 | Indiana State v South Dakota | W | 10-38 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | L | 23-31 |
| NCAAF | 2021/09/19 00:00 | South Dakota v Cal Poly | W | 48-14 |
| NCAAF | 2021/09/11 18:00 | Northern Arizona v South Dakota | W | 7-34 |
| NCAAF | 2021/09/04 00:00 | South Dakota v Kansas | L | 14-17 |
Away History
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | W | 31-38 |
| NCAAF | 2021/10/23 19:00 | Western Illinois v North Dakota | L | 10-34 |
| NCAAF | 2021/10/16 17:00 | South Dakota State v Western Illinois | L | 41-17 |
| NCAAF | 2021/10/09 17:00 | Western Illinois v Indiana State | L | 27-37 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | L | 31-30 |
| NCAAF | 2021/09/25 22:00 | Western Illinois v Youngstown State | W | 38-35 |
| NCAAF | 2021/09/18 20:00 | East Washington v Western Illinois | L | 62-56 |
| NCAAF | 2021/09/12 00:00 | Western Illinois v Montana | L | 7-42 |