Stadium: O'Brien Stadium Round: 1
Home Manager: Adam Cushing Away Manager: Brock Spack
| NCAAF | 2019/09/14 19:00 | Illinois State v Eastern Illinois | W | 21-3 |
| NCAAF | 2018/09/08 23:30 | Eastern Illinois v Illinois State | W | 10-48 |
| NCAAF | 2017/09/16 19:00 | Eastern Illinois v Illinois State | W | 13-44 |
| NCAAF | 2021/09/11 21:00 | Illinois State v Western Michigan | L | 0-28 |
| NCAAF | 2021/09/04 23:30 | Butler v Illinois State | W | 7-49 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | W | 18-26 |
| NCAAF | 2021/03/13 20:30 | Illinois State v North Dakota State | L | 13-21 |
| NCAAF | 2021/03/06 22:00 | Illinois State v Northern Iowa | L | 10-20 |
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | L | 27-20 |
| NCAAF | 2019/12/14 17:00 | Illinois State v North Dakota State | L | 3-9 |
| NCAAF | 2019/12/07 20:00 | Illinois State v Central Arkansas | W | 24-14 |
| NCAAF | 2021/09/11 17:00 | Eastern Illinois v Dayton | L | 10-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | L | 0-46 |
| NCAAF | 2021/08/28 22:00 | Eastern Illinois v Indiana State | L | 21-26 |
| NCAAF | 2021/04/03 18:00 | Jacksonville State v Eastern Illinois | L | 44-23 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | L | 27-41 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | W | 20-28 |
| NCAAF | 2021/03/14 18:00 | Eastern Illinois v Tennessee State | L | 20-21 |
| NCAAF | 2021/03/07 19:00 | Eastern Illinois v Tennessee Martin | L | 15-28 |