[96] Southern Miss 14-63 Alabama [21] 2021-09-25 23:30
Stadium: Bryant-Denny Stadium Round: 1
Home Manager: Nick Saban Away Manager: Will Hall
Head to Head
| NCAAF | 2019/09/21 16:00 | Southern Mississippi v Alabama | L | 7-49 |
| NCAAF | 2014/09/13 22:00 | Alabama v Southern Mississippi | L | 52-12 |
| NCAAF | 2005/09/10 12:00 | Alabama v Southern Mississippi | L | 30-21 |
| NCAAF | 2004/10/16 12:00 | Alabama v Southern Mississippi | L | 27-3 |
| NCAAF | 2003/10/11 12:00 | Alabama v Southern Mississippi | L | 17-3 |
| NCAAF | 2002/09/21 12:00 | Alabama v Southern Mississippi | L | 20-7 |
| NCAAF | 2001/11/29 12:00 | Alabama v Southern Mississippi | L | 28-15 |
| NCAAF | 2000/09/16 12:00 | Alabama v Southern Mississippi | W | 0-21 |
Home History
| NCAAF | 2021/09/18 23:00 | Troy v Southern Mississippi | L | 21-9 |
| NCAAF | 2021/09/11 23:00 | Grambling State v Southern Mississippi | W | 0-37 |
| NCAAF | 2021/09/05 00:00 | Southern Mississippi v South Alabama | L | 7-31 |
| NCAAF | 2020/12/10 23:30 | Florida Atlantic v Southern Mississippi | W | 31-45 |
| NCAAF | 2020/11/21 20:00 | Texas-San Antonio v Southern Mississippi | L | 23-20 |
| NCAAF | 2020/11/14 20:30 | Southern Mississippi v Western Kentucky | L | 7-10 |
| NCAAF | 2020/11/07 20:00 | North Alabama v Southern Mississippi | W | 13-24 |
| NCAAF | 2020/10/31 19:00 | Rice v Southern Mississippi | L | 30-6 |
Away History
| NCAAF | 2021/09/25 21:00 | Tuskegee v Alabama | W | 35-45 |
| NCAAF | 2021/09/18 19:30 | Alabama v Florida | W | 31-29 |
| NCAAF | 2021/09/16 23:30 | Alabama v Bethune Cookman | W | 30-27 |
| NCAAF | 2021/09/11 20:00 | Mercer v Alabama | W | 14-48 |
| NCAAF | 2021/09/04 23:00 | South Carolina State v Alabama | W | 41-42 |
| NCAAF | 2021/09/04 19:30 | Alabama v Miami Florida | W | 44-13 |
| NCAAF | 2021/05/01 19:00 | Alabama v Arkansas Pine Bluff | W | 40-33 |
| NCAAF | 2021/04/17 23:30 | Alabama v Alabama State | W | 38-14 |