[96] Southern Miss 14-63 Alabama [21] 2021-09-25 23:30
Stadium: Bryant-Denny Stadium Round: 1
Home Manager: Nick Saban Away Manager: Will Hall
Head to Head
| NCAAF | 2019/09/21 16:00 | Southern Mississippi v Alabama | L | 7-49 |
| NCAAF | 2014/09/13 22:00 | Alabama v Southern Mississippi | L | 52-12 |
| NCAAF | 2005/09/10 12:00 | Alabama v Southern Mississippi | L | 30-21 |
| NCAAF | 2004/10/16 12:00 | Alabama v Southern Mississippi | L | 27-3 |
| NCAAF | 2003/10/11 12:00 | Alabama v Southern Mississippi | L | 17-3 |
| NCAAF | 2002/09/21 12:00 | Alabama v Southern Mississippi | L | 20-7 |
| NCAAF | 2001/11/29 12:00 | Alabama v Southern Mississippi | L | 28-15 |
| NCAAF | 2000/09/16 12:00 | Alabama v Southern Mississippi | W | 0-21 |