[125] South Florida 13-17 Central Florida [35] 2021-11-26 20:30
Stadium: Spectrum Stadium Round: 1
Home Manager: Gus Malzahn Away Manager: Jeff Scott
Head to Head
| NCAAF | 2020/11/27 20:30 | Central Florida v South Florida | L | 58-46 |
| NCAAF | 2019/11/30 01:00 | South Florida v Central Florida | L | 7-34 |
| NCAAF | 2018/11/23 21:00 | Central Florida v South Florida | L | 38-10 |
| NCAAF | 2017/11/24 20:30 | South Florida v Central Florida | L | 42-49 |
| NCAAF | 2016/11/26 17:00 | Central Florida v South Florida | W | 31-48 |
| NCAAF | 2015/11/27 00:30 | Central Florida v South Florida | W | 3-44 |
| NCAAF | 2014/11/28 17:00 | South Florida v Central Florida | L | 0-16 |
| NCAAF | 2008/09/06 12:00 | Central Florida v South Florida | W | 24-31 |
Home History
| NCAAF | 2021/11/20 17:00 | South Florida v Tulane | L | 14-45 |
| NCAAF | 2021/11/12 23:00 | Cincinnati v South Florida | L | 45-28 |
| NCAAF | 2021/11/06 23:30 | Houston v South Florida | L | 54-42 |
| NCAAF | 2021/10/28 23:30 | South Florida v East Carolina | L | 14-29 |
| NCAAF | 2021/10/23 23:00 | Temple v South Florida | W | 14-34 |
| NCAAF | 2021/10/16 16:00 | Tulsa v South Florida | L | 32-31 |
| NCAAF | 2021/10/02 20:00 | South Florida v SMU | L | 17-41 |
| NCAAF | 2021/09/26 02:15 | South Florida v BYU | L | 27-35 |
Away History
| NCAAF | 2021/11/20 21:00 | Connecticut v Central Florida | W | 17-49 |
| NCAAF | 2021/11/13 17:00 | Central Florida v SMU | L | 28-55 |
| NCAAF | 2021/11/06 20:00 | Tulane v Central Florida | W | 10-14 |
| NCAAF | 2021/10/30 16:00 | Central Florida v Temple | W | 49-7 |
| NCAAF | 2021/10/22 23:00 | Memphis v Central Florida | W | 7-24 |
| NCAAF | 2021/10/16 16:00 | Central Florida v Cincinnati | L | 21-56 |
| NCAAF | 2021/10/09 22:00 | East Carolina v Central Florida | W | 16-20 |
| NCAAF | 2021/10/02 19:30 | Central Florida v Navy | L | 30-34 |