[35] Penn State 24-33 Ohio State [16] 2021-10-30 23:30
Stadium: Ohio Stadium Round: 1
Home Manager: Ryan Day Away Manager: James Franklin
Head to Head
| NCAAF | 2020/10/31 23:30 | Ohio State v Penn State | L | 38-25 |
| NCAAF | 2019/11/23 17:00 | Penn State v Ohio State | L | 17-28 |
| NCAAF | 2018/09/29 23:30 | Ohio State v Penn State | L | 27-26 |
| NCAAF | 2017/10/28 19:30 | Penn State v Ohio State | L | 38-39 |
| NCAAF | 2016/10/23 00:00 | Ohio State v Penn State | W | 21-24 |
| NCAAF | 2015/10/18 00:00 | Ohio State v Penn State | L | 38-10 |
| NCAAF | 2014/10/26 00:00 | Penn State v Ohio State | L | 24-31 |
| NCAAF | 2012/10/27 12:00 | Penn State v Ohio State | L | 23-35 |
Home History
| NCAAF | 2021/10/23 16:00 | Illinois v Penn State | L | 20-18 |
| NCAAF | 2021/10/09 20:00 | Penn State v Iowa | L | 20-23 |
| NCAAF | 2021/10/02 23:30 | Indiana v Penn State | W | 0-24 |
| NCAAF | 2021/09/25 16:00 | Villanova v Penn State | W | 17-38 |
| NCAAF | 2021/09/18 23:30 | Auburn v Penn State | W | 20-28 |
| NCAAF | 2021/09/11 19:30 | Ball State v Penn State | W | 13-44 |
| NCAAF | 2021/09/04 16:00 | Penn State v Wisconsin | W | 16-10 |
| NCAAF | 2020/12/19 22:30 | Illinois v Penn State | W | 21-56 |
Away History
| NCAAF | 2021/10/23 23:30 | Ohio State v Indiana | W | 54-7 |
| NCAAF | 2021/10/09 16:00 | Maryland v Ohio State | W | 17-66 |
| NCAAF | 2021/10/02 19:30 | Ohio State v Rutgers | W | 52-13 |
| NCAAF | 2021/09/25 23:30 | Akron v Ohio State | W | 7-59 |
| NCAAF | 2021/09/18 19:30 | Tulsa v Ohio State | W | 20-41 |
| NCAAF | 2021/09/11 16:00 | Oregon v Ohio State | L | 35-28 |
| NCAAF | 2021/09/03 00:00 | Ohio State v Minnesota | W | 45-31 |
| NCAAF | 2021/01/12 01:15 | Ohio State v Alabama | L | 24-52 |