[35] Penn State 24-33 Ohio State [16] 2021-10-30 23:30
Stadium: Ohio Stadium Round: 1
Home Manager: Ryan Day Away Manager: James Franklin
Head to Head
| NCAAF | 2020/10/31 23:30 | Ohio State v Penn State | L | 38-25 |
| NCAAF | 2019/11/23 17:00 | Penn State v Ohio State | L | 17-28 |
| NCAAF | 2018/09/29 23:30 | Ohio State v Penn State | L | 27-26 |
| NCAAF | 2017/10/28 19:30 | Penn State v Ohio State | L | 38-39 |
| NCAAF | 2016/10/23 00:00 | Ohio State v Penn State | W | 21-24 |
| NCAAF | 2015/10/18 00:00 | Ohio State v Penn State | L | 38-10 |
| NCAAF | 2014/10/26 00:00 | Penn State v Ohio State | L | 24-31 |
| NCAAF | 2012/10/27 12:00 | Penn State v Ohio State | L | 23-35 |
| NCAAF | 2011/11/19 12:00 | Ohio State v Penn State | W | 14-20 |
| NCAAF | 2010/11/13 12:00 | Ohio State v Penn State | L | 38-14 |
| NCAAF | 2009/11/07 12:00 | Penn State v Ohio State | L | 7-24 |
| NCAAF | 2008/10/25 12:00 | Ohio State v Penn State | W | 6-13 |
| NCAAF | 2007/10/27 12:00 | Penn State v Ohio State | L | 17-37 |
| NCAAF | 2006/09/23 12:00 | Ohio State v Penn State | L | 28-6 |
| NCAAF | 2005/10/08 12:00 | Penn State v Ohio State | W | 17-10 |
| NCAAF | 2004/10/30 12:00 | Ohio State v Penn State | L | 21-10 |
| NCAAF | 2003/11/01 12:00 | Penn State v Ohio State | L | 20-21 |
| NCAAF | 2002/10/26 12:00 | Ohio State v Penn State | L | 13-7 |
| NCAAF | 2001/10/27 12:00 | Penn State v Ohio State | W | 29-27 |
| NCAAF | 2000/09/23 12:00 | Ohio State v Penn State | L | 45-6 |