[109] South Florida 14-29 East Carolina [95] 2021-10-28 23:30
Stadium: Bagwell Field at Dowdy-Ficklen Stadium Round: 1
Home Manager: Mike Houston Away Manager: Jeff Scott
Head to Head
| NCAAF | 2020/10/10 23:00 | East Carolina v South Florida | L | 44-24 |
| NCAAF | 2019/10/26 19:45 | South Florida v East Carolina | W | 45-20 |
| NCAAF | 2018/09/23 00:00 | East Carolina v South Florida | W | 13-20 |
| NCAAF | 2017/09/30 16:00 | East Carolina v South Florida | W | 31-61 |
| NCAAF | 2016/10/08 16:00 | South Florida v East Carolina | W | 38-22 |
| NCAAF | 2015/11/08 00:30 | East Carolina v South Florida | W | 17-22 |
| NCAAF | 2014/10/11 23:00 | South Florida v East Carolina | L | 17-28 |
| NCAAF Bowl Games | 2006/12/23 12:00 | East Carolina v South Florida | W | 7-24 |
Home History
| NCAAF | 2021/10/23 23:00 | Temple v South Florida | W | 14-34 |
| NCAAF | 2021/10/16 16:00 | Tulsa v South Florida | L | 32-31 |
| NCAAF | 2021/10/02 20:00 | South Florida v SMU | L | 17-41 |
| NCAAF | 2021/09/26 02:15 | South Florida v BYU | L | 27-35 |
| NCAAF | 2021/09/18 23:00 | Florida A&M v South Florida | W | 17-38 |
| NCAAF | 2021/09/11 17:00 | Florida v South Florida | L | 42-20 |
| NCAAF | 2021/09/02 23:30 | South Florida v NC State | L | 0-45 |
| NCAAF | 2020/11/27 20:30 | Central Florida v South Florida | L | 58-46 |
Away History
| NCAAF | 2021/10/24 01:20 | East Carolina v Houston | L | 24-31 |
| NCAAF | 2021/10/09 22:00 | East Carolina v Central Florida | L | 16-20 |
| NCAAF | 2021/10/02 19:30 | Tulane v East Carolina | W | 29-52 |
| NCAAF | 2021/09/25 22:00 | Charleston Southern v East Carolina | W | 28-31 |
| NCAAF | 2021/09/18 22:00 | East Carolina v Marshall | W | 42-38 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | L | 20-17 |
| NCAAF | 2021/09/02 23:30 | East Carolina v Appalachian St | L | 19-33 |
| NCAAF | 2020/11/28 17:00 | SMU v East Carolina | W | 38-52 |