[109] South Florida 14-29 East Carolina [95] 2021-10-28 23:30
Stadium: Bagwell Field at Dowdy-Ficklen Stadium Round: 1
Home Manager: Mike Houston Away Manager: Jeff Scott
Head to Head
| NCAAF | 2020/10/10 23:00 | East Carolina v South Florida | L | 44-24 |
| NCAAF | 2019/10/26 19:45 | South Florida v East Carolina | W | 45-20 |
| NCAAF | 2018/09/23 00:00 | East Carolina v South Florida | W | 13-20 |
| NCAAF | 2017/09/30 16:00 | East Carolina v South Florida | W | 31-61 |
| NCAAF | 2016/10/08 16:00 | South Florida v East Carolina | W | 38-22 |
| NCAAF | 2015/11/08 00:30 | East Carolina v South Florida | W | 17-22 |
| NCAAF | 2014/10/11 23:00 | South Florida v East Carolina | L | 17-28 |
| NCAAF Bowl Games | 2006/12/23 12:00 | East Carolina v South Florida | W | 7-24 |
| NCAAF | 2004/11/13 12:00 | South Florida v East Carolina | W | 41-17 |
| NCAAF | 2003/11/08 12:00 | East Carolina v South Florida | W | 37-38 |
| NCAAF | 2002/10/19 12:00 | East Carolina v South Florida | W | 30-46 |