[15] Houston 54-42 South Florida [113] 2021-11-06 23:30
Stadium: Raymond James Stadium Round: 1
Home Manager: Jeff Scott Away Manager: Dana Holgorsen
Head to Head
| NCAAF | 2020/11/14 20:30 | South Florida v Houston | W | 21-56 |
| NCAAF | 2018/10/27 19:30 | South Florida v Houston | W | 36-57 |
| NCAAF | 2017/10/28 19:45 | Houston v South Florida | W | 28-24 |
| NCAAF | 2014/11/01 20:00 | South Florida v Houston | W | 3-27 |
| NCAAF | 2002/11/23 12:00 | Houston v South Florida | L | 14-32 |
| NCAAF | 2001/11/03 12:00 | South Florida v Houston | L | 45-6 |
Home History
| NCAAF | 2021/10/30 23:00 | SMU v Houston | W | 37-44 |
| NCAAF | 2021/10/24 01:20 | East Carolina v Houston | W | 24-31 |
| NCAAF | 2021/10/07 23:30 | Houston v Tulane | W | 40-22 |
| NCAAF | 2021/10/01 23:30 | Houston v Tulsa | W | 45-10 |
| NCAAF | 2021/09/25 23:00 | Navy v Houston | W | 20-28 |
| NCAAF | 2021/09/18 23:00 | Grambling State v Houston | W | 0-45 |
| NCAAF | 2021/09/11 22:30 | Houston v Rice | W | 44-7 |
| NCAAF | 2021/09/04 23:00 | Texas Tech v Houston | L | 38-21 |
Away History
| NCAAF | 2021/10/28 23:30 | South Florida v East Carolina | L | 14-29 |
| NCAAF | 2021/10/23 23:00 | Temple v South Florida | W | 14-34 |
| NCAAF | 2021/10/16 16:00 | Tulsa v South Florida | L | 32-31 |
| NCAAF | 2021/10/02 20:00 | South Florida v SMU | L | 17-41 |
| NCAAF | 2021/09/26 02:15 | South Florida v BYU | L | 27-35 |
| NCAAF | 2021/09/18 23:00 | Florida A&M v South Florida | W | 17-38 |
| NCAAF | 2021/09/11 17:00 | Florida v South Florida | L | 42-20 |
| NCAAF | 2021/09/02 23:30 | South Florida v NC State | L | 0-45 |