[15] Houston 54-42 South Florida [113] 2021-11-06 23:30
Stadium: Raymond James Stadium Round: 1
Home Manager: Jeff Scott Away Manager: Dana Holgorsen
Head to Head
| NCAAF | 2020/11/14 20:30 | South Florida v Houston | W | 21-56 |
| NCAAF | 2018/10/27 19:30 | South Florida v Houston | W | 36-57 |
| NCAAF | 2017/10/28 19:45 | Houston v South Florida | W | 28-24 |
| NCAAF | 2014/11/01 20:00 | South Florida v Houston | W | 3-27 |
| NCAAF | 2002/11/23 12:00 | Houston v South Florida | L | 14-32 |
| NCAAF | 2001/11/03 12:00 | South Florida v Houston | L | 45-6 |