[13] Purdue 13-27 Notre Dame [49] 2021-09-18 18:30
Stadium: Notre Dame Stadium Round: 1
Home Manager: Brian Kelly Away Manager: Jeff Brohm
Head to Head
| NCAAF | 2014/09/13 23:30 | Notre Dame v Purdue | L | 30-14 |
| NCAAF | 2012/09/08 12:00 | Notre Dame v Purdue | L | 20-17 |
| NCAAF | 2011/10/01 12:00 | Purdue v Notre Dame | L | 10-38 |
| NCAAF | 2010/09/04 12:00 | Notre Dame v Purdue | L | 23-12 |
| NCAAF | 2009/09/26 12:00 | Purdue v Notre Dame | L | 21-24 |
| NCAAF | 2008/09/27 12:00 | Notre Dame v Purdue | L | 38-21 |
| NCAAF | 2007/09/29 12:00 | Purdue v Notre Dame | W | 33-19 |
| NCAAF | 2006/09/30 12:00 | Notre Dame v Purdue | L | 35-21 |
Home History
| NCAAF | 2021/09/11 19:00 | Purdue v Connecticut | W | 49-0 |
| NCAAF | 2021/09/04 23:00 | Oregon State v Purdue | W | 21-30 |
| NCAAF | 2020/12/05 17:00 | Nebraska v Purdue | L | 37-27 |
| NCAAF | 2020/11/28 21:00 | Rutgers v Purdue | L | 37-30 |
| NCAAF | 2020/11/21 00:30 | Purdue v Minnesota | L | 31-34 |
| NCAAF | 2020/11/14 22:00 | Northwestern v Purdue | L | 27-20 |
| NCAAF | 2020/10/31 16:00 | Purdue v Illinois | W | 31-24 |
| NCAAF | 2020/10/24 19:30 | Iowa v Purdue | W | 20-24 |
Away History
| NCAAF | 2021/09/11 18:30 | Toledo v Notre Dame | W | 29-32 |
| NCAAF | 2021/09/05 23:30 | Notre Dame v Florida State | W | 41-38 |
| NCAAF | 2021/01/01 21:00 | Notre Dame v Alabama | L | 14-31 |
| NCAAF | 2020/12/19 21:00 | Clemson v Notre Dame | L | 34-10 |
| NCAAF | 2020/12/05 19:30 | Syracuse v Notre Dame | W | 21-45 |
| NCAAF | 2020/11/27 20:30 | Notre Dame v North Carolina | W | 31-17 |
| NCAAF | 2020/11/14 20:30 | Notre Dame v Boston College | W | 45-31 |
| NCAAF | 2020/11/08 00:30 | Clemson v Notre Dame | W | 40-47 |