[13] Purdue 13-27 Notre Dame [49] 2021-09-18 18:30
Stadium: Notre Dame Stadium Round: 1
Home Manager: Brian Kelly Away Manager: Jeff Brohm
Head to Head
| NCAAF | 2014/09/13 23:30 | Notre Dame v Purdue | L | 30-14 |
| NCAAF | 2012/09/08 12:00 | Notre Dame v Purdue | L | 20-17 |
| NCAAF | 2011/10/01 12:00 | Purdue v Notre Dame | L | 10-38 |
| NCAAF | 2010/09/04 12:00 | Notre Dame v Purdue | L | 23-12 |
| NCAAF | 2009/09/26 12:00 | Purdue v Notre Dame | L | 21-24 |
| NCAAF | 2008/09/27 12:00 | Notre Dame v Purdue | L | 38-21 |
| NCAAF | 2007/09/29 12:00 | Purdue v Notre Dame | W | 33-19 |
| NCAAF | 2006/09/30 12:00 | Notre Dame v Purdue | L | 35-21 |
| NCAAF | 2005/10/01 12:00 | Purdue v Notre Dame | L | 28-49 |
| NCAAF | 2004/10/02 12:00 | Notre Dame v Purdue | W | 16-41 |
| NCAAF | 2003/09/27 12:00 | Purdue v Notre Dame | W | 23-10 |
| NCAAF | 2002/09/07 12:00 | Notre Dame v Purdue | L | 24-17 |
| NCAAF | 2001/12/01 12:00 | Purdue v Notre Dame | L | 18-24 |
| NCAAF | 2000/09/16 12:00 | Notre Dame v Purdue | L | 23-21 |