[47] Louisville 34-37 Wake Forest [9] 2021-10-02 16:30
Stadium: Allegacy Federal Credit Union Stadium Round: 1
Home Manager: Dave Clawson Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2019/10/12 23:30 | Louisville v Wake Forest | W | 62-59 |
| NCAAF | 2018/10/27 16:00 | Wake Forest v Louisville | L | 56-35 |
| NCAAF | 2017/10/28 16:20 | Louisville v Wake Forest | L | 32-42 |
| NCAAF | 2016/11/13 00:00 | Wake Forest v Louisville | W | 12-44 |
| NCAAF | 2015/10/30 23:00 | Wake Forest v Louisville | W | 19-20 |
| NCAAF | 2014/09/27 19:30 | Louisville v Wake Forest | W | 20-10 |
| NCAAF Bowl Games | 2007/01/02 12:00 | Louisville v Wake Forest | W | 24-13 |
Home History
| NCAAF | 2021/09/25 19:30 | Louisville v Florida State | W | 31-23 |
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | W | 35-42 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | W | 3-30 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |
Away History
| NCAAF | 2021/09/24 23:00 | Wake Forest v Virginia | W | 37-17 |
| NCAAF | 2021/09/18 19:30 | Florida State v Wake Forest | W | 14-35 |
| NCAAF | 2021/09/11 16:00 | Norfolk State v Wake Forest | W | 16-41 |
| NCAAF | 2021/09/03 23:00 | Old Dominion v Wake Forest | W | 10-42 |
| NCAAF | 2020/12/30 17:00 | Wisconsin v Wake Forest | L | 42-28 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | L | 21-45 |
| NCAAF | 2020/11/14 17:00 | Wake Forest v North Carolina | L | 53-59 |
| NCAAF | 2020/10/31 16:00 | Wake Forest v Syracuse | W | 38-14 |