[47] Louisville 34-37 Wake Forest [9] 2021-10-02 16:30
Stadium: Allegacy Federal Credit Union Stadium Round: 1
Home Manager: Dave Clawson Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2019/10/12 23:30 | Louisville v Wake Forest | W | 62-59 |
| NCAAF | 2018/10/27 16:00 | Wake Forest v Louisville | L | 56-35 |
| NCAAF | 2017/10/28 16:20 | Louisville v Wake Forest | L | 32-42 |
| NCAAF | 2016/11/13 00:00 | Wake Forest v Louisville | W | 12-44 |
| NCAAF | 2015/10/30 23:00 | Wake Forest v Louisville | W | 19-20 |
| NCAAF | 2014/09/27 19:30 | Louisville v Wake Forest | W | 20-10 |
| NCAAF Bowl Games | 2007/01/02 12:00 | Louisville v Wake Forest | W | 24-13 |