[79] Mississippi State 45-6 Vanderbilt [113] 2021-10-23 20:00
Stadium: Vanderbilt Stadium Round: 1
Home Manager: Clark Lea Away Manager: Mike Leach
Head to Head
| NCAAF | 2020/11/07 20:30 | Vanderbilt v Mississippi State | W | 17-24 |
| NCAAF | 2014/11/23 00:30 | Mississippi State v Vanderbilt | W | 51-0 |
| NCAAF | 2009/09/19 12:00 | Vanderbilt v Mississippi State | W | 3-15 |
| NCAAF | 2008/10/11 12:00 | Mississippi State v Vanderbilt | W | 17-14 |
| NCAAF | 2004/10/02 12:00 | Vanderbilt v Mississippi State | L | 31-13 |
| NCAAF | 2003/10/04 12:00 | Mississippi State v Vanderbilt | W | 30-21 |
Home History
| NCAAF | 2021/10/16 23:00 | Alabama v Mississippi State | L | 49-9 |
| NCAAF | 2021/10/02 23:00 | Mississippi State v Texas A&M | W | 26-22 |
| NCAAF | 2021/09/25 16:00 | LSU v Mississippi State | L | 28-25 |
| NCAAF | 2021/09/18 20:00 | Mississippi State v Memphis | L | 29-31 |
| NCAAF | 2021/09/11 23:00 | NC State v Mississippi State | W | 10-24 |
| NCAAF | 2021/09/04 20:00 | Louisiana Tech v Mississippi State | W | 34-35 |
| NCAAF | 2020/12/31 17:00 | Mississippi State v Tulsa | W | 28-26 |
| NCAAF | 2020/12/19 20:30 | Missouri v Mississippi State | W | 32-51 |
Away History
| NCAAF | 2021/10/16 20:00 | Vanderbilt v South Carolina | L | 20-21 |
| NCAAF | 2021/10/09 16:00 | Vanderbilt v Florida | L | 0-42 |
| NCAAF | 2021/10/02 23:30 | Connecticut v Vanderbilt | W | 28-30 |
| NCAAF | 2021/09/25 16:00 | Georgia v Vanderbilt | L | 62-0 |
| NCAAF | 2021/09/19 00:00 | Stanford v Vanderbilt | L | 41-23 |
| NCAAF | 2021/09/12 02:00 | Vanderbilt v Colorado State | W | 24-21 |
| NCAAF | 2021/09/05 00:00 | East Tennessee State v Vanderbilt | L | 23-3 |
| NCAAF | 2020/12/12 21:00 | Tennessee v Vanderbilt | L | 42-17 |