[46] Louisville 31-23 Florida State [123] 2021-09-25 19:30
Stadium: Bobby Bowden Field at Doak Campbell Stadium Round: 1
Home Manager: Mike Norvell Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | W | 16-48 |
| NCAAF | 2019/09/21 19:30 | Louisville v Florida State | L | 24-35 |
| NCAAF | 2018/09/29 19:30 | Florida State v Louisville | L | 28-24 |
| NCAAF | 2017/10/21 16:00 | Florida State v Louisville | W | 28-31 |
| NCAAF | 2017/10/21 16:00 | Louisville v Florida State | W | 31-28 |
| NCAAF | 2016/09/17 16:00 | Florida State v Louisville | W | 20-63 |
| NCAAF | 2015/10/17 16:00 | Florida State v Louisville | L | 41-21 |
| NCAAF | 2014/10/30 23:30 | Louisville v Florida State | L | 31-42 |
Home History
| NCAAF | 2021/09/17 23:30 | Central Florida v Louisville | W | 35-42 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | W | 3-30 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | L | 24-43 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | W | 21-45 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2020/11/14 20:30 | Louisville v Virginia | L | 17-31 |
| NCAAF | 2020/10/31 20:00 | Virginia Tech v Louisville | L | 42-35 |
Away History
| NCAAF | 2021/09/18 19:30 | Florida State v Wake Forest | L | 14-35 |
| NCAAF | 2021/09/12 00:00 | Jacksonville State v Florida State | L | 20-17 |
| NCAAF | 2021/09/05 23:30 | Notre Dame v Florida State | L | 41-38 |
| NCAAF | 2020/12/12 21:00 | Duke v Florida State | W | 35-56 |
| NCAAF | 2020/11/15 00:30 | Florida State v NC State | L | 22-38 |
| NCAAF | 2020/11/07 21:00 | Pittsburgh v Florida State | L | 41-17 |
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | L | 16-48 |
| NCAAF | 2020/10/17 23:30 | North Carolina v Florida State | W | 28-31 |