[46] Louisville 31-23 Florida State [123] 2021-09-25 19:30
Stadium: Bobby Bowden Field at Doak Campbell Stadium Round: 1
Home Manager: Mike Norvell Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2020/10/24 16:00 | Florida State v Louisville | W | 16-48 |
| NCAAF | 2019/09/21 19:30 | Louisville v Florida State | L | 24-35 |
| NCAAF | 2018/09/29 19:30 | Florida State v Louisville | L | 28-24 |
| NCAAF | 2017/10/21 16:00 | Florida State v Louisville | W | 28-31 |
| NCAAF | 2017/10/21 16:00 | Louisville v Florida State | W | 31-28 |
| NCAAF | 2016/09/17 16:00 | Florida State v Louisville | W | 20-63 |
| NCAAF | 2015/10/17 16:00 | Florida State v Louisville | L | 41-21 |
| NCAAF | 2014/10/30 23:30 | Louisville v Florida State | L | 31-42 |
| NCAAF | 2002/09/26 12:00 | Louisville v Florida State | W | 26-20 |
| NCAAF | 2000/09/23 12:00 | Florida State v Louisville | L | 31-0 |