[34] Northern Illinois 33-27 Buffalo [89] 2021-11-18 00:00
Stadium: UB Stadium Round: 1
Home Manager: Maurice Linguist Away Manager: Thomas Hammock
Head to Head
| NCAAF | 2020/11/05 00:00 | Buffalo v Northern Illinois | L | 49-30 |
| NCAAF | 2018/12/01 00:00 | Northern Illinois v Buffalo | W | 30-29 |
| NCAAF | 2017/10/14 19:30 | Northern Illinois v Buffalo | W | 14-13 |
| NCAAF | 2016/10/22 19:30 | Buffalo v Northern Illinois | W | 7-44 |
| NCAAF | 2015/11/12 01:00 | Buffalo v Northern Illinois | W | 30-41 |
| NCAAF | 2012/10/13 12:00 | Northern Illinois v Buffalo | W | 45-3 |
| NCAAF | 2011/10/22 12:00 | Buffalo v Northern Illinois | W | 30-31 |
| NCAAF | 2010/10/16 12:00 | Northern Illinois v Buffalo | W | 45-14 |
Home History
| NCAAF | 2021/11/11 00:00 | Ball State v Northern Illinois | W | 29-30 |
| NCAAF | 2021/11/03 23:00 | Northern Illinois v Kent State | L | 47-52 |
| NCAAF | 2021/10/23 16:00 | Northern Illinois v Central Michigan | W | 39-38 |
| NCAAF | 2021/10/16 19:30 | Bowling Green v Northern Illinois | W | 26-34 |
| NCAAF | 2021/10/09 16:00 | Northern Illinois v Toledo | W | 22-20 |
| NCAAF | 2021/10/02 18:30 | Eastern Michigan v Northern Illinois | W | 20-27 |
| NCAAF | 2021/09/25 18:30 | Maine v Northern Illinois | W | 14-41 |
| NCAAF | 2021/09/18 16:00 | Northern Illinois v Michigan | L | 10-63 |
Away History
| NCAAF | 2021/11/10 00:00 | Buffalo v Miami Ohio | L | 18-45 |
| NCAAF | 2021/10/30 16:00 | Bowling Green v Buffalo | L | 56-44 |
| NCAAF | 2021/10/23 19:30 | Buffalo v Akron | W | 45-10 |
| NCAAF | 2021/10/16 16:00 | Ohio v Buffalo | W | 26-27 |
| NCAAF | 2021/10/09 23:00 | Buffalo v Kent State | L | 38-48 |
| NCAAF | 2021/10/02 16:00 | Western Michigan v Buffalo | L | 24-17 |
| NCAAF | 2021/09/25 22:00 | Buffalo v Old Dominion | W | 35-34 |
| NCAAF | 2021/09/18 16:00 | Coastal Carolina v Buffalo | L | 28-25 |