[6] Texas San Antonio 45-16 Louisiana Tech [106] 2021-10-23 23:00
Stadium: Joe Aillet Stadium Round: 1
Home Manager: Skip Holtz Away Manager: Jeff Traylor
Head to Head
| NCAAF | 2020/10/25 00:00 | Louisiana Tech v Texas-San Antonio | W | 26-27 |
| NCAAF | 2019/11/30 20:30 | Texas-San Antonio v Louisiana Tech | L | 27-41 |
| NCAAF | 2018/10/13 23:00 | Louisiana Tech v Texas-San Antonio | L | 31-3 |
| NCAAF | 2017/11/26 00:30 | Texas-San Antonio v Louisiana Tech | L | 6-20 |
| NCAAF | 2016/11/12 20:30 | Texas-San Antonio v Louisiana Tech | L | 35-63 |
| NCAAF | 2015/10/10 23:00 | Texas-San Antonio v Louisiana Tech | L | 31-34 |
| NCAAF | 2014/10/18 16:00 | Louisiana Tech v Texas-San Antonio | L | 27-20 |
| NCAAF | 2012/11/03 12:00 | Louisiana Tech v Texas-San Antonio | L | 51-27 |
Home History
| NCAAF | 2021/10/16 22:00 | Rice v Texas-San Antonio | W | 0-45 |
| NCAAF | 2021/10/09 23:00 | Texas-San Antonio v Western Kentucky | W | 52-46 |
| NCAAF | 2021/10/02 22:00 | UNLV v Texas-San Antonio | W | 17-24 |
| NCAAF | 2021/09/25 19:30 | Texas-San Antonio v Memphis | W | 31-28 |
| NCAAF | 2021/09/18 22:00 | Middle Tennessee St. v Texas-San Antonio | W | 13-27 |
| NCAAF | 2021/09/11 22:00 | Lamar v Texas-San Antonio | W | 0-54 |
| NCAAF | 2021/09/04 23:30 | Texas-San Antonio v Illinois | W | 37-30 |
| NCAAF | 2020/12/26 20:30 | Lafayette v Texas-San Antonio | L | 31-24 |
Away History
| NCAAF | 2021/10/17 01:00 | Louisiana Tech v UTEP | L | 3-19 |
| NCAAF | 2021/10/02 22:00 | Louisiana Tech v NC State | L | 27-34 |
| NCAAF | 2021/09/25 23:00 | North Texas v Louisiana Tech | W | 17-24 |
| NCAAF | 2021/09/18 19:30 | SMU v Louisiana Tech | L | 39-37 |
| NCAAF | 2021/09/11 23:00 | SE Louisiana v Louisiana Tech | W | 42-45 |
| NCAAF | 2021/09/04 20:00 | Louisiana Tech v Mississippi State | L | 34-35 |
| NCAAF | 2020/12/23 20:00 | Georgia Southern v Louisiana Tech | L | 38-3 |
| NCAAF | 2020/12/13 00:00 | Louisiana Tech v TCU | L | 10-52 |