[6] Texas San Antonio 45-16 Louisiana Tech [106] 2021-10-23 23:00
Stadium: Joe Aillet Stadium Round: 1
Home Manager: Skip Holtz Away Manager: Jeff Traylor
Head to Head
| NCAAF | 2020/10/25 00:00 | Louisiana Tech v Texas-San Antonio | W | 26-27 |
| NCAAF | 2019/11/30 20:30 | Texas-San Antonio v Louisiana Tech | L | 27-41 |
| NCAAF | 2018/10/13 23:00 | Louisiana Tech v Texas-San Antonio | L | 31-3 |
| NCAAF | 2017/11/26 00:30 | Texas-San Antonio v Louisiana Tech | L | 6-20 |
| NCAAF | 2016/11/12 20:30 | Texas-San Antonio v Louisiana Tech | L | 35-63 |
| NCAAF | 2015/10/10 23:00 | Texas-San Antonio v Louisiana Tech | L | 31-34 |
| NCAAF | 2014/10/18 16:00 | Louisiana Tech v Texas-San Antonio | L | 27-20 |
| NCAAF | 2012/11/03 12:00 | Louisiana Tech v Texas-San Antonio | L | 51-27 |