[127] Southern Miss 35-19 Louisiana Tech [105] 2021-11-20 01:00
Stadium: Joe Aillet Stadium Round: 1
Home Manager: Skip Holtz Away Manager: Will Hall
Head to Head
| NCAAF | 2020/09/19 23:30 | Louisiana Tech v Southern Mississippi | L | 31-30 |
| NCAAF | 2019/10/19 19:30 | Southern Mississippi v Louisiana Tech | L | 30-45 |
| NCAAF | 2018/11/17 20:30 | Louisiana Tech v Southern Mississippi | W | 20-21 |
| NCAAF | 2017/10/21 23:00 | Southern Mississippi v Louisiana Tech | W | 34-27 |
| NCAAF | 2016/11/25 21:00 | Louisiana Tech v Southern Mississippi | W | 24-39 |
| NCAAF | 2015/11/28 17:00 | Louisiana Tech v Southern Mississippi | W | 24-58 |
| NCAAF | 2014/10/25 19:30 | Southern Mississippi v Louisiana Tech | L | 20-31 |
| NCAAF | 2011/09/03 12:00 | Southern Mississippi v Louisiana Tech | W | 19-17 |
Home History
| NCAAF | 2021/11/13 20:30 | Southern Mississippi v Texas-San Antonio | L | 17-27 |
| NCAAF | 2021/11/06 19:00 | North Texas v Southern Mississippi | L | 38-14 |
| NCAAF | 2021/10/30 19:30 | Southern Mississippi v Middle Tennessee St. | L | 10-35 |
| NCAAF | 2021/10/16 19:30 | UAB v Southern Mississippi | L | 34-0 |
| NCAAF | 2021/10/09 23:00 | UTEP v Southern Mississippi | L | 26-13 |
| NCAAF | 2021/10/02 22:30 | Southern Mississippi v Rice | L | 19-24 |
| NCAAF | 2021/09/25 23:30 | Southern Mississippi v Alabama | L | 14-63 |
| NCAAF | 2021/09/18 23:00 | Troy v Southern Mississippi | L | 21-9 |
Away History
| NCAAF | 2021/11/13 20:30 | Charlotte v Louisiana Tech | W | 32-42 |
| NCAAF | 2021/11/06 16:00 | Louisiana Tech v UAB | L | 38-52 |
| NCAAF | 2021/10/30 19:30 | Louisiana Tech v Old Dominion | L | 20-23 |
| NCAAF | 2021/10/23 23:00 | Texas-San Antonio v Louisiana Tech | L | 45-16 |
| NCAAF | 2021/10/17 01:00 | Louisiana Tech v UTEP | L | 3-19 |
| NCAAF | 2021/10/02 22:00 | Louisiana Tech v NC State | L | 27-34 |
| NCAAF | 2021/09/25 23:00 | North Texas v Louisiana Tech | W | 17-24 |
| NCAAF | 2021/09/18 19:30 | SMU v Louisiana Tech | L | 39-37 |