[127] Southern Miss 35-19 Louisiana Tech [105] 2021-11-20 01:00
Stadium: Joe Aillet Stadium Round: 1
Home Manager: Skip Holtz Away Manager: Will Hall
Head to Head
| NCAAF | 2020/09/19 23:30 | Louisiana Tech v Southern Mississippi | L | 31-30 |
| NCAAF | 2019/10/19 19:30 | Southern Mississippi v Louisiana Tech | L | 30-45 |
| NCAAF | 2018/11/17 20:30 | Louisiana Tech v Southern Mississippi | W | 20-21 |
| NCAAF | 2017/10/21 23:00 | Southern Mississippi v Louisiana Tech | W | 34-27 |
| NCAAF | 2016/11/25 21:00 | Louisiana Tech v Southern Mississippi | W | 24-39 |
| NCAAF | 2015/11/28 17:00 | Louisiana Tech v Southern Mississippi | W | 24-58 |
| NCAAF | 2014/10/25 19:30 | Southern Mississippi v Louisiana Tech | L | 20-31 |
| NCAAF | 2011/09/03 12:00 | Southern Mississippi v Louisiana Tech | W | 19-17 |
| NCAAF | 2010/09/25 12:00 | Louisiana Tech v Southern Mississippi | W | 12-13 |