[115] East Carolina 42-38 Marshall [13] 2021-09-18 22:00
Stadium: Joan C. Edwards Stadium Round: 1
Home Manager: Charles Huff Away Manager: Mike Houston
Head to Head
| NCAAF | 2012/11/23 12:00 | East Carolina v Marshall | W | 65-59 |
| NCAAF | 2011/11/26 12:00 | Marshall v East Carolina | L | 34-27 |
| NCAAF | 2010/10/23 12:00 | East Carolina v Marshall | W | 37-10 |
| NCAAF | 2008/11/08 12:00 | East Carolina v Marshall | W | 19-16 |
| NCAAF | 2007/11/10 12:00 | Marshall v East Carolina | L | 26-7 |
| NCAAF | 2006/11/11 12:00 | East Carolina v Marshall | W | 33-20 |
| NCAAF | 2005/11/19 12:00 | Marshall v East Carolina | W | 29-34 |
| NCAAF Bowl Games | 2001/12/19 12:00 | East Carolina v Marshall | L | 61-64 |
Home History
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | L | 20-17 |
| NCAAF | 2021/09/02 23:30 | East Carolina v Appalachian St | L | 19-33 |
| NCAAF | 2020/11/28 17:00 | SMU v East Carolina | W | 38-52 |
| NCAAF | 2020/11/21 17:00 | East Carolina v Temple | W | 28-3 |
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | L | 17-55 |
| NCAAF | 2020/11/07 17:00 | Tulane v East Carolina | L | 38-21 |
| NCAAF | 2020/10/31 01:00 | East Carolina v Tulsa | L | 30-34 |
| NCAAF | 2020/10/17 16:00 | Navy v East Carolina | L | 27-23 |
Away History
| NCAAF | 2021/09/11 22:30 | North Carolina Central v Marshall | W | 10-44 |
| NCAAF | 2021/09/04 19:30 | Marshall v Navy | W | 49-7 |
| NCAAF | 2020/12/25 19:30 | Marshall v Buffalo | L | 10-17 |
| NCAAF | 2020/12/19 00:00 | UAB v Marshall | L | 22-13 |
| NCAAF | 2020/12/05 17:00 | Rice v Marshall | L | 20-0 |
| NCAAF | 2020/11/14 17:00 | Middle Tennessee St. v Marshall | W | 14-42 |
| NCAAF | 2020/11/07 19:30 | Massachusetts v Marshall | W | 10-51 |
| NCAAF | 2020/10/24 18:30 | Florida Atlantic v Marshall | W | 9-20 |