[115] East Carolina 42-38 Marshall [13] 2021-09-18 22:00
Stadium: Joan C. Edwards Stadium Round: 1
Home Manager: Charles Huff Away Manager: Mike Houston
Head to Head
| NCAAF | 2012/11/23 12:00 | East Carolina v Marshall | W | 65-59 |
| NCAAF | 2011/11/26 12:00 | Marshall v East Carolina | L | 34-27 |
| NCAAF | 2010/10/23 12:00 | East Carolina v Marshall | W | 37-10 |
| NCAAF | 2008/11/08 12:00 | East Carolina v Marshall | W | 19-16 |
| NCAAF | 2007/11/10 12:00 | Marshall v East Carolina | L | 26-7 |
| NCAAF | 2006/11/11 12:00 | East Carolina v Marshall | W | 33-20 |
| NCAAF | 2005/11/19 12:00 | Marshall v East Carolina | W | 29-34 |
| NCAAF Bowl Games | 2001/12/19 12:00 | East Carolina v Marshall | L | 61-64 |