[121] Southern Miss 10-35 Middle Tennessee [94] 2021-10-30 19:30
Stadium: Johnny "Red" Floyd Stadium Round: 1
Home Manager: Rick Stockstill Away Manager: Will Hall
Head to Head
| NCAAF | 2014/10/04 16:00 | Middle Tennessee St. v Southern Mississippi | L | 37-31 |
| NCAAF Bowl Games | 2009/12/20 12:00 | Middle Tennessee St. v Southern Mississippi | L | 42-32 |
Home History
| NCAAF | 2021/10/16 19:30 | UAB v Southern Mississippi | L | 34-0 |
| NCAAF | 2021/10/09 23:00 | UTEP v Southern Mississippi | L | 26-13 |
| NCAAF | 2021/10/02 22:30 | Southern Mississippi v Rice | L | 19-24 |
| NCAAF | 2021/09/25 23:30 | Southern Mississippi v Alabama | L | 14-63 |
| NCAAF | 2021/09/18 23:00 | Troy v Southern Mississippi | L | 21-9 |
| NCAAF | 2021/09/11 23:00 | Grambling State v Southern Mississippi | W | 0-37 |
| NCAAF | 2021/09/05 00:00 | Southern Mississippi v South Alabama | L | 7-31 |
| NCAAF | 2020/12/10 23:30 | Florida Atlantic v Southern Mississippi | W | 31-45 |
Away History
| NCAAF | 2021/10/22 22:00 | Middle Tennessee St. v Connecticut | W | 44-13 |
| NCAAF | 2021/10/09 19:30 | Middle Tennessee St. v Liberty | L | 13-41 |
| NCAAF | 2021/10/02 23:00 | Marshall v Middle Tennessee St. | W | 28-34 |
| NCAAF | 2021/09/24 22:30 | Middle Tennessee St. v Charlotte | L | 39-42 |
| NCAAF | 2021/09/18 22:00 | Middle Tennessee St. v Texas-San Antonio | L | 13-27 |
| NCAAF | 2021/09/11 18:00 | Middle Tennessee St. v Virginia Tech | L | 14-35 |
| NCAAF | 2021/09/04 23:00 | Monmouth v Middle Tennessee St. | W | 15-50 |
| NCAAF | 2020/11/21 20:30 | Middle Tennessee St. v Troy | W | 20-17 |