[121] Southern Miss 10-35 Middle Tennessee [94] 2021-10-30 19:30
Stadium: Johnny "Red" Floyd Stadium Round: 1
Home Manager: Rick Stockstill Away Manager: Will Hall
Head to Head
| NCAAF | 2014/10/04 16:00 | Middle Tennessee St. v Southern Mississippi | L | 37-31 |
| NCAAF Bowl Games | 2009/12/20 12:00 | Middle Tennessee St. v Southern Mississippi | L | 42-32 |