Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Bubba Schweigert
| NCAAF | 2021/11/13 20:00 | Illinois State v North Dakota | W | 7-14 |
| NCAAF | 2021/11/06 17:00 | Youngstown State v North Dakota | W | 21-24 |
| NCAAF | 2021/10/30 19:00 | North Dakota v Missouri St | L | 28-32 |
| NCAAF | 2021/10/23 19:00 | Western Illinois v North Dakota | W | 10-34 |
| NCAAF | 2021/10/16 19:00 | North Dakota v SO Illinois | L | 28-31 |
| NCAAF | 2021/10/09 19:00 | North Dakota v South Dakota | L | 13-20 |
| NCAAF | 2021/10/02 19:00 | North Dakota State v North Dakota | L | 16-10 |
| NCAAF | 2021/09/18 21:00 | Drake Bulldogs v North Dakota | W | 0-38 |
| NCAAF | 2021/11/13 19:00 | South Dakota State v South Dakota | L | 20-23 |
| NCAAF | 2021/11/06 19:00 | North Dakota State v South Dakota State | W | 19-27 |
| NCAAF | 2021/10/30 18:00 | South Dakota State v Youngstown State | W | 47-16 |
| NCAAF | 2021/10/23 19:00 | Northern Iowa v South Dakota State | L | 26-17 |
| NCAAF | 2021/10/16 17:00 | South Dakota State v Western Illinois | W | 41-17 |
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | L | 42-41 |
| NCAAF | 2021/10/02 23:00 | Utah Tech v South Dakota State | W | 7-55 |
| NCAAF | 2021/09/25 17:00 | South Dakota State v Indiana State | W | 44-0 |