Murray State 20-13 Eastern Illinois 2021-11-20 18:00
Stadium: O'Brien Stadium Round: 1
Home Manager: Adam Cushing Away Manager: Dean Hood
Head to Head
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | W | 6-22 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | W | 27-41 |
| NCAAF | 2019/10/05 18:00 | Eastern Illinois v Murray State | W | 17-24 |
| NCAAF | 2018/10/06 23:00 | Murray State v Eastern Illinois | W | 48-41 |
| NCAAF | 2017/10/14 20:00 | Murray State v Eastern Illinois | L | 24-27 |
Home History
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | W | 10-28 |
| NCAAF | 2021/11/06 18:00 | Tennessee Tech v Murray State | W | 27-32 |
| NCAAF | 2021/10/30 22:00 | Murray State v Tennessee State | L | 21-27 |
| NCAAF | 2021/10/23 19:00 | Austin Peay v Murray State | L | 47-6 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | W | 32-31 |
| NCAAF | 2021/10/09 19:00 | Murray State v Tennessee Martin | L | 24-48 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | W | 6-22 |
| NCAAF | 2021/09/18 21:00 | Murray State v Bowling Green | L | 10-27 |
Away History
| NCAAF | 2021/11/06 19:00 | Eastern Illinois v Austin Peay | L | 26-42 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | L | 15-38 |
| NCAAF | 2021/10/23 19:00 | Tennessee State v Eastern Illinois | L | 28-0 |
| NCAAF | 2021/10/16 19:00 | Tennessee Martin v Eastern Illinois | L | 28-17 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | L | 6-22 |
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | W | 28-14 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | L | 31-24 |
| NCAAF | 2021/09/11 17:00 | Eastern Illinois v Dayton | L | 10-17 |