Murray State 20-13 Eastern Illinois 2021-11-20 18:00
Stadium: O'Brien Stadium Round: 1
Home Manager: Adam Cushing Away Manager: Dean Hood
Head to Head
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | W | 6-22 |
| NCAAF | 2021/03/28 19:00 | Eastern Illinois v Murray State | W | 27-41 |
| NCAAF | 2019/10/05 18:00 | Eastern Illinois v Murray State | W | 17-24 |
| NCAAF | 2018/10/06 23:00 | Murray State v Eastern Illinois | W | 48-41 |
| NCAAF | 2017/10/14 20:00 | Murray State v Eastern Illinois | L | 24-27 |