[109] Vanderbilt 20-21 South Carolina [66] 2021-10-16 20:00
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Shane Beamer Away Manager: Clark Lea
Head to Head
| NCAAF | 2020/10/10 16:00 | South Carolina v Vanderbilt | L | 41-7 |
| NCAAF | 2019/11/02 23:30 | Vanderbilt v South Carolina | L | 7-24 |
| NCAAF | 2018/09/22 20:00 | South Carolina v Vanderbilt | L | 37-14 |
| NCAAF | 2017/10/28 20:00 | Vanderbilt v South Carolina | L | 27-34 |
| NCAAF | 2016/09/02 00:00 | South Carolina v Vanderbilt | L | 13-10 |
| NCAAF | 2015/10/17 20:00 | South Carolina v Vanderbilt | L | 19-10 |
| NCAAF | 2014/09/20 23:30 | Vanderbilt v South Carolina | L | 34-48 |
| NCAAF | 2012/08/30 12:00 | Vanderbilt v South Carolina | L | 13-17 |
Home History
| NCAAF | 2021/10/09 16:00 | Vanderbilt v Florida | L | 0-42 |
| NCAAF | 2021/10/02 23:30 | Connecticut v Vanderbilt | W | 28-30 |
| NCAAF | 2021/09/25 16:00 | Georgia v Vanderbilt | L | 62-0 |
| NCAAF | 2021/09/19 00:00 | Stanford v Vanderbilt | L | 41-23 |
| NCAAF | 2021/09/12 02:00 | Vanderbilt v Colorado State | W | 24-21 |
| NCAAF | 2021/09/05 00:00 | East Tennessee State v Vanderbilt | L | 23-3 |
| NCAAF | 2020/12/12 21:00 | Tennessee v Vanderbilt | L | 42-17 |
| NCAAF | 2020/11/28 17:00 | Vanderbilt v Missouri | L | 0-41 |
Away History
| NCAAF | 2021/10/09 16:00 | South Carolina v Tennessee | L | 20-45 |
| NCAAF | 2021/10/02 19:30 | Troy v South Carolina | W | 14-23 |
| NCAAF | 2021/09/25 23:00 | Kentucky v South Carolina | L | 16-10 |
| NCAAF | 2021/09/18 23:00 | South Carolina v Georgia | L | 13-40 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | W | 20-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | W | 0-46 |
| NCAAF | 2020/12/06 00:30 | South Carolina v Kentucky | L | 18-41 |
| NCAAF | 2020/11/29 00:30 | Georgia v South Carolina | L | 45-16 |