[109] Vanderbilt 20-21 South Carolina [66] 2021-10-16 20:00
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Shane Beamer Away Manager: Clark Lea
Head to Head
| NCAAF | 2020/10/10 16:00 | South Carolina v Vanderbilt | L | 41-7 |
| NCAAF | 2019/11/02 23:30 | Vanderbilt v South Carolina | L | 7-24 |
| NCAAF | 2018/09/22 20:00 | South Carolina v Vanderbilt | L | 37-14 |
| NCAAF | 2017/10/28 20:00 | Vanderbilt v South Carolina | L | 27-34 |
| NCAAF | 2016/09/02 00:00 | South Carolina v Vanderbilt | L | 13-10 |
| NCAAF | 2015/10/17 20:00 | South Carolina v Vanderbilt | L | 19-10 |
| NCAAF | 2014/09/20 23:30 | Vanderbilt v South Carolina | L | 34-48 |
| NCAAF | 2012/08/30 12:00 | Vanderbilt v South Carolina | L | 13-17 |
| NCAAF | 2011/09/24 12:00 | South Carolina v Vanderbilt | L | 21-3 |
| NCAAF | 2010/10/23 12:00 | Vanderbilt v South Carolina | L | 7-21 |
| NCAAF | 2009/10/24 12:00 | South Carolina v Vanderbilt | L | 14-10 |
| NCAAF | 2008/09/04 12:00 | Vanderbilt v South Carolina | W | 24-17 |
| NCAAF | 2007/10/20 12:00 | South Carolina v Vanderbilt | W | 6-17 |
| NCAAF | 2006/10/21 12:00 | Vanderbilt v South Carolina | L | 13-31 |
| NCAAF | 2005/10/22 12:00 | South Carolina v Vanderbilt | L | 35-28 |
| NCAAF | 2004/09/04 12:00 | Vanderbilt v South Carolina | L | 6-31 |
| NCAAF | 2003/10/25 12:00 | South Carolina v Vanderbilt | L | 35-24 |
| NCAAF | 2002/09/28 12:00 | Vanderbilt v South Carolina | L | 14-20 |
| NCAAF | 2001/10/20 12:00 | South Carolina v Vanderbilt | L | 46-14 |
| NCAAF | 2000/10/21 12:00 | Vanderbilt v South Carolina | L | 14-30 |